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Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Suppression of obsessive–compulsive symptoms after epilepsy surgery

2005; Elsevier BV; Volume: 7; Issue: 2 Linguagem: Inglês

10.1016/j.yebeh.2005.05.024

1525-5069

Ricardo Guarnieri, David Araújo, Carlos Gilberto Carlotti, João Alberto Assirati, Jaime E. C. Hallak, Tonicarlo Rodrigues Velasco, V. Alexandre, Vera C. Terra, Roger Walz, Marino M. Bianchin, Lauro Wichert‐Ana, Maria Beatriz Martins Linhares, Charles L. Dalmagro, Luciana Midori Inuzuka, Américo Ceiki Sakamoto,

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes

We report two male patients with medically intractable epilepsy and obsessive–compulsive disorder (OCD) symptoms. Both patients experienced remission of obsessive–compulsive symptoms after surgical treatment of epilepsy. Although the surgeries targeted different brain regions, the two patients had in common unilateral anterior cingulate cortex ablation. On the basis of these observations, we discuss the pathophysiology of OCD symptoms, emphasizing the role of corticosubcortical pathways in their genesis. Our data suggest that surgeries that affect neural loops associated with obsessive–compulsive symptoms can lead to an improvement of OCD; however, the structures responsible for this effect cannot be conclusively determined.