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One-Pot Synthesis of Benzofurans via Palladium-Catalyzed Enolate Arylation with o -Bromophenols

2008; American Chemical Society; Volume: 10; Issue: 19 Linguagem: Inglês

10.1021/ol801510n

1523-7060

Christian Eidamshaus, Jason D. Burch,

Asymmetric Synthesis and Catalysis

A one-pot synthesis of benzofurans which utilizes a palladium-catalyzed enolate arylation is described. The process demonstrates broad substrate scope and provides differentially substituted benzofurans in moderate to excellent yields. The utility of the method is further demonstrated by the synthesis of the natural product eupomatenoid 6 in three steps.