Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans
2013; Elsevier BV; Volume: 122; Issue: 13 Linguagem: Inglês
10.1182/blood-2013-03-488411
ISSN1528-0020
AutoresLiset Westera, Julia Drylewicz, Ineke den Braber, Tendai Mugwagwa, I. Maas, Lydia M. Kwast, Thomas J. H. Volman, Elise H. R. van de Weg-Schrijver, István Bartha, G. Th. Spierenburg, Koos Gaiser, Mariëtte T. Ackermans, Becca Asquith, Rob J. de Boer, Kiki Tesselaar, José A. M. Borghans,
Tópico(s)Tryptophan and brain disorders
ResumoKey Points Life span estimates can be sensitive to the duration of stable isotope label administration, explaining discrepancies in the literature. Multiexponential models are needed to obtain reliable leukocyte life span estimates.
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