Anti-inflammatory Effects of Mao-Bushi-Saishin-to in Mice and Rats
1998; World Scientific; Volume: 26; Issue: 02 Linguagem: Inglês
10.1142/s0192415x98000221
ISSN1793-6853
AutoresYoshiki Ikeda, Osamu T. Iijima, Akira lizuka, Atsushi Ishige, Sakae Amagaya, Yasuhiro Komatsu, Minoru Okada, Chiyuki Abe, Eiichi Fujihira,
Tópico(s)Olfactory and Sensory Function Studies
ResumoEffects of Mao-Bushi-Saishin-to (MBS) on anti-inflammatory activities were examined in mice and rats. MBS significantly inhibited the increase in vascular permeability induced by acetic acid, the ear edema induced by arachidonic acid and phorbol ester, and the cutaneous extravasation induced by bradykinin and histamine. MBS, however, was not effective against the serotonin-induced cutaneous permeability increase in mice. MBS significantly inhibited carrageenin-induced hind foot edema and cotton pellet-induced granulation tissue growth in rats. These results show that MBS may exert anti-inflammatory effects through the underlying mechanism(s) of preventing mediator release from mast cells and macrophages.
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