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cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988; American Association for the Advancement of Science; Volume: 241; Issue: 4865 Linguagem: Inglês

10.1126/science.2969618

1095-9203

John E. Sims, Caril J. March, David Cosman, Michael B. Widmer, H. Robson MacDonald, Catherine J. McMahan, C. E. Grubin, J Wignall, Jana L. Jackson, Susan M. Call, Della Friend, A Alpert, Steven Gillis, David L. Urdal, Steven Dower,

Immunotherapy and Immune Responses

Interleukin-1 alpha and -1 beta (IL-1α and IL-1β) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1α and IL-1β in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.