Iron and Diabetes Risk
2013; Cell Press; Volume: 17; Issue: 3 Linguagem: Inglês
10.1016/j.cmet.2013.02.007
ISSN1932-7420
AutoresJudith Simcox, Donald A. McClain,
Tópico(s)Folate and B Vitamins Research
ResumoIron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions—hereditary hemochromatosis and thalassemia—but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by β cell failure and insulin resistance. Iron also regulates metabolism in most tissues involved in fuel homeostasis, with the adipocyte in particular serving an iron-sensing role. The underlying molecular mechanisms mediating these effects are numerous and incompletely understood but include oxidant stress and modulation of adipokines and intracellular signal transduction pathways.
Referência(s)