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Effects of amlodipine on blood pressure, heart rate, catecholamines, lipids and responses to adrenergic stimulus

1990; Elsevier BV; Volume: 66; Issue: 17 Linguagem: Inglês

10.1016/0002-9149(90)91118-p

1879-1913

Larry M. Lopez, Alfred D. Thorman, Jawahar L. Mehta,

Heart Rate Variability and Autonomic Control

Management of systemic hypertension with calcium antagonists is gaining increasing acceptance.1 Anti-hypertensive therapy with these agents, however, is limited by frequent adverse effects and need for frequent daily doses. Amlodipine is a new dihydropyridine derivative currently undergoing evaluation for therapy of hypertension. Although qualitatively similar to nifedipine, amlodipine has a longer duration of action and may be useful as a single daily dose.2 This study evaluated effects of different doses of amlodipine given once daily to patients with mild to moderate hypertension. Its effects on adrenergic response to isometric exercise3 and plasma levels of catecholamines and lipids were also evaluated.