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Chloral hydrate inhibits protein synthesis in vivo

1971; Elsevier BV; Volume: 238; Issue: 2 Linguagem: Inglês

10.1016/0005-2787(71)90101-8

1879-3002

Daniel McMahon, William Blaschko,

Nitric Oxide and Endothelin Effects

A wide variety of substances can produce the unique inhibition of cell division characterized as c-mitosis and can also induce anesthesia. One of these is chloral hydrate. It is more active, on the basis of its physical properties, than other compounds with the same effects. We investigated the basis of its unique effectiveness for the inhibition of cell division using the protozoan, Chlamydomonas reinhardii. At a concentration which inhibits cell division, it completely inhibits protein synthesis in vivo, but has only slight effects on a number of other cellular functions. This inhibition is sufficient to explain its inhibition of cell division. In addition it is possible that this inhibition of protein synthesis by chloral hydrate may be relevant to its effects on the central nervous system.