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THE INOTROPIC EFFECT OF l -NORADRENALINE IN EXPERIMENTAL CARDIOGENIC SHOCK

1965; NRC Research Press; Volume: 43; Issue: 1 Linguagem: Inglês

10.1139/y65-007

1205-7541

R. F. P. Cronin, Eng Huat Tan,

Cardiac Arrest and Resuscitation

The hemodynamic effects of noradrenaline infusion (1 μg/kg min) were studied in five normal dogs and in five dogs in whom cardiogenic shock had been produced by closed-chest coronary embolization.Noradrenaline infusion caused a significant increase in arterial blood pressure, cardiac output, and mean left-atrial pressure in all animals. In the shocked group, the observed increase in cardiac output was significantly less than in the control group.The inotropic effect of infused noradrenaline was quantitated in each animal by comparing the increase in left-ventricular stroke work evoked by noradrenaline with the increase in stroke work which occurred when the mean left-atrial pressure was elevated by autologous transfusion to the level previously attained during noradrenaline infusion. In the control animals, noradrenaline increased left-ventricular stroke work an average of 91% for an average increase in mean left-atrial pressure of 5.6 mm Hg while transfusion increased left-ventricular stroke work 72% for a similar rise in left-atrial pressure. In the shocked animals, noradrenaline increased left-ventricular stroke work 120% but transfusion increased it only 35% for a similar increase in mean left-atrial pressure.It is concluded that the inotropic effect of noradrenaline is enhanced in experimental cardiogenic shock.