Produção Nacional
Revisado por pares
Psoriasis and Pentoxifylline: A Clinical, Histopathologic, and Immunohistochemical Evaluation
2006; Wiley; Volume: 5; Issue: 6 Linguagem: Inglês
10.1111/j.1540-9740.2006.05681.x
ISSN1751-7125
AutoresGeraldo Magela Magalhães, Sueli Coelho da Silva Carneiro, Karla Peisino Do Amaral, Flávia de Freire Cassia, Jackson Machado‐Pinto, Tullia Cuzzi,
Tópico(s)Immunotoxicology and immune responses
ResumoThe aim of this study was to examine the clinical and histopathologic effects of pentoxifylline on psoriasis, compared with placebo.Sixty-one outpatients with active psoriasis were randomly assigned to either of 2 groups: one was given pentoxifylline 400 mg tid PO, and the other, placebo. Fifty-six patients concluded the study. They were evaluated clinically and by laboratory parameters before and after 8 weeks of treatment. Pretreatment and posttreatment biopsies were taken. Initial sections were stained with hematoxylin-eosin. Further cuts were immunostained for cytokeratins 10, 14, and 16.Clinical and histologic improvement did not show statistically significant differences between the groups. No laboratory abnormalities or serious reactions related to the drug were observed.No statistical difference was seen when the treatment group was compared with the control group. Pentoxifylline is a well tolerated and safe drug, but its efficacy in psoriasis appears to be limited.
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