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Long-term follow-up of Lambert-Eaton syndrome treated with intravenous immunoglobulin

1997; Wiley; Volume: 20; Issue: 6 Linguagem: Inglês

10.1002/(sici)1097-4598(199706)20

1097-4598

S Muchnik, Adriana S. Losavio, Alfredo Vidal, Leila Cura, Claudio Mazia,

Vascular Malformations and Hemangiomas

Muscle & NerveVolume 20, Issue 6 p. 674-678 Main Article Long-term follow-up of Lambert-Eaton syndrome treated with intravenous immunoglobulin Salomon Muchnik MD, PhD, Corresponding Author Salomon Muchnik MD, PhD Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaInstituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaSearch for more papers by this authorAdriana S. Losavio MD, PhD, Adriana S. Losavio MD, PhD Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaSearch for more papers by this authorAlfredo Vidal MD, Alfredo Vidal MD Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaSearch for more papers by this authorLeila Cura MD, Leila Cura MD Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaSearch for more papers by this authorClaudio Mazia MD, Claudio Mazia MD Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaSearch for more papers by this author Salomon Muchnik MD, PhD, Corresponding Author Salomon Muchnik MD, PhD Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaInstituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaSearch for more papers by this authorAdriana S. Losavio MD, PhD, Adriana S. Losavio MD, PhD Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaSearch for more papers by this authorAlfredo Vidal MD, Alfredo Vidal MD Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaSearch for more papers by this authorLeila Cura MD, Leila Cura MD Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaSearch for more papers by this authorClaudio Mazia MD, Claudio Mazia MD Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, ArgentinaSearch for more papers by this author First published: 07 December 1998 https://doi.org/10.1002/(SICI)1097-4598(199706)20:6 3.0.CO;2-5Citations: 25AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Recent reports have shown that patients with Lambert-Eaton myasthenic syndrome (LEMS) improve transiently after high-dose intravenous immunoglobulin (IVIG) administration. Information about the usefulness of IVIG for long-term treatment is rather scanty. Our findings demonstrate the efficacy of monthly IVIG courses at a dose of 0.4 g/kg/day for 5 days, in a 41-year-old patient with LEMS without detectable malignancy. Improvement in limb strength, peak expiratory flow rate, and electrophysiological parameters, as well as clinical signs following IVIG, was evident as early as 7 days after the first course and is still maintained at 24-months follow-up. © 1997 John Wiley & Sons, Inc. Muscle Nerve, 20, 674–678, 1997. Citing Literature Volume20, Issue6June 1997Pages 674-678 RelatedInformation