Portal de Periódicos da CAPES

Psoriatic Fibroblasts Induce Hyperproliferation of Normal Keratinocytes in a Skin Equivalent Model in Vitro

1985; American Association for the Advancement of Science; Volume: 230; Issue: 4726 Linguagem: Inglês

10.1126/science.2413549

1095-9203

P. Saïag, Bernard Coulomb, Corinne Lebreton, Eugene Bell, Louis Dubertret,

Cellular Mechanics and Interactions

A skin equivalent model has been used to fabricate tissues with psoriatic and normal cells. Psoriatic fibroblasts can induce hyperproliferative activity in normal keratinocytes. The psoriatic epidermis from lesions continues to proliferate at high rates for at least 15 days in this model, and normal fibroblasts are unable to suppress this hyperproliferation. The primary defect in psoriatic skin may reside in the dermal fibroblast.