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Human exposure to mercury: The three modern dilemmas

2003; Wiley; Volume: 16; Issue: 4 Linguagem: Inglês

10.1002/jtra.10050

1520-670X

Thomas W. Clarkson, L. Magós, Gary J. Myers,

Air Quality and Health Impacts

The Journal of Trace Elements in Experimental MedicineVolume 16, Issue 4 p. 321-343 Original Article Human exposure to mercury: The three modern dilemmas Thomas W. Clarkson, Corresponding Author Thomas W. Clarkson [email protected] Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New YorkDepartment of Environmental Medicine, Box EHSC, University of Rochester School of Medicine, Rochester, NY 14642Search for more papers by this authorLaszlo Magos, Laszlo Magos Medical Research Council Laboratories, (Retired), Carshalton, United KingdomSearch for more papers by this authorGary J. Myers, Gary J. Myers Departments of Neurology and Pediatrics, University of Rochester School of Medicine, Rochester, New YorkSearch for more papers by this author Thomas W. Clarkson, Corresponding Author Thomas W. Clarkson [email protected] Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New YorkDepartment of Environmental Medicine, Box EHSC, University of Rochester School of Medicine, Rochester, NY 14642Search for more papers by this authorLaszlo Magos, Laszlo Magos Medical Research Council Laboratories, (Retired), Carshalton, United KingdomSearch for more papers by this authorGary J. Myers, Gary J. Myers Departments of Neurology and Pediatrics, University of Rochester School of Medicine, Rochester, New YorkSearch for more papers by this author First published: 22 October 2003 https://doi.org/10.1002/jtra.10050Citations: 63AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Polson CJ, Tattersall RN. Clinical toxicology. London: The English University Press; 1959. 2 Goldwater LJ. Mercury: a history of quicksilver. Baltimore: York Press; 1972. 3 Ramazzini B (1713) Diseases of Workers. (Translated by Wilmer Cave Wright) New York: Hafner Publishing. Company; 1964. p 42. 4 Warkany J, Hubbard DM. Acrodynia and mercury. J Pediatr 1953; 42: 365–386. 5 FAO-WHO. Toxicological evaluation of certain food additives with a review of general principles and of specifications. Seventeenth report of the joint FAO-WHO Expert Committee on Food Additives. World Health organization Technical Report Series. 1974; 539: 1–40. 6 Cleary D. Anatomy of the amazon gold rush. Iowa City, Iowa: University of Iowa Press; 1990. 7 ATSDR. Toxicological profile for mercury. Agency for Toxic substances and disease. Atlanta: Division of Toxicology, US Department of Health and Human Services, Public Health Service; 1999. 8 Clarkson TW. The three modern faces of mercury. Environ Health Perspect 2002; 110 (suppl 1): 11–23. 9 Frykholm KO. On mercury from dental amalgam, its toxic and allergic effects. Acta Odontol Scand 1957; 5 (suppl 22): 17. 10 Hunter D. Diseases of occupations. Boston: Little Brown & Co; 1969. p 314–328. 11 Newland MC, Warfinge K, Berlin M. Behavioral consequences of in utero exposure to mercury vapor: alterations in lever-press durations and learning in squirrel monkeys. Toxicol Appl Pharmacol 1996; 139: 374–386. 12 WHO. Environmental Health Criteria 118. Inorganic Mercury. International program on Chemical Safety. Geneva: World Health Organization; 1991. 13 WHO. Environmental Health Criteria 101: Methyl mercury. International Program on Chemical Safety, Geneva: World Health Organization; 1990. 14 Kingman A, Albertini T, Brown LJ. Mercury concentrations in urine and whole blood associated with amalgam exposure in a US military population. J Dent Res 1998; 77: 461–467. 15 Sallsten G, Thoren J, Barregard L, Schutz A, Skarping G. Long-term use of nicotine chewing gum and mercury exposure from dental amalgam fillings. J Dent Res 1996; 75: 594–598. 16 Thompson CM, Markesbery WR, Ehmann WD, Mao YX, Vance DE. Regional brain trace-element studies in Alzheimer's disease. Neurotoxicology 1998; 9: 1–7. 17 Chadwick DJ, Whelan J. Aluminium in Biology and Medicine. Ciba Foundation Symposium 169. Chichester: John Wiley & Sons; 1992. 18 Ahlqwist M, Bengtsson C, Laipus L, Gergdahl IA, Schutz A. Serum mercury concentration in relation to survival, symptoms and disease: results from a prospective population study of women in Gothenburg, Sweden. Acta Odontl Scand 1999; 57: 168–174. 19 Bjorkman L, Pedersen NNL, Lichtenstein P. Physical and mental health related to dental amalgam fillings in Swedish twins. Comm Dent Oral Epidemiol 1996; 24: 260–267. 20 Saxe SR, Snowden DA, Wekstein MW, Henry RG, Grant FT, Donegan SJ, Wekstein DR. Dental amalgam and cognitive function in older women: findings from the Nun Study. J Am Dent Assoc 1995; 126: 1495–1501. 21 Reichl FX, Walther U, Durner J, Kehe K, Hickel R, Kunzelmann KH, Spahl W, Hume WR, Benschop H, Forth W. Cytotoxicity of dental composite components and mercury compounds in lung cells. Dent Mater 2001; 17: 95–101. 22 Heil J, Reifferscheid G, Waldmann P, Leyhausen G, Geurtsen W. Genotoxicity of dental materials. Mutat Res 1996; 368: 181–194. 23 Molin M, Bergman B, Marklund SL, Schutz A, Skerfving S. Mercury, selenium and glutathione peroxidase before and after amalgam removal in man. Acta Odontol Scand 1990; 48: 189–202. 24 EPA. Water quality criterion for the protection of human health: methyl mercury. Office of Science and Technology, Office of Water, US Environmental Protection Agency, Washington DC 20460, EPA0823-R-01–001, 2001. 25 WHO. Environmental Health Criteria 1: Mercury. Geneva: World Health Organization; 1976. 26 Bakir F, Damluji SF, Amin-Zaki L, Murtadha M, Khalidi A, al-Rawi NY, S, Dahir H. Methyl mercury poisoning in Iraq. Science 1973; 181: 230–241 27 Greenwood MR. Methylmercury poisoning in Iraq: an epidemiological study of the 1971–72 outbreak. J Appl Toxicol 1985; 5: 148–159. 28 Jernelov A. Conversion of mercury compounds. In: MW Miller, GG Berg, editors. Chemical fallout. Springfield, IL: Charles C. Thomas; 1969. p 68–74. 29 Johnels AG, Westermark T. Mercury contamination in the environment in Sweden. In: MM Miller, GG Berg, editors. Chemical Fallout. Springfield, IL: Charles C. Thomas; 1969. p 221–241. 30 McAlpine D, Araki S. Minamata disease: An unusual neurological disaster caused by contaminated fish. Lancet 1958; 2: 629–631 31 Irikayama, K. Case history of Minamata. In: T Tsubaki, J Irukayama, editors. Minamata disease, Tokyo: Kodansha Ltd and Elsevier Publishing Company; 1997. p 12. 32 Takeuchi T, Komyo E. The pathology of Minamata disease. Kyushu: Kyushu University Press; 1999. p 18. 33 Pfeiffer WC, Lacerda LD. Mercury inputs in the Amazon region. Environ Technol Lett 1988; 9: 325–330. 34 Fitzgerald WF, Clarkson TW. Mercury and monomethyl mercury: present and future concerns. Environ Health Perspect 1991; 96: 159–166. 35 Fitzgerald WF, Mason RP. Biogeochemical cycle of mercury in the marine environment. In: A Sigel, H Sigel, editors. Metal Ions in Biological Systems. New York: Marcel Dekker; 1997; pp 53–111. 36 Muckle G, Ayotte P, Dewailly EE, Jacobson SW, Jacobson JL. Prenatal exposure of the northern Quebec Inuit infants to environmental contaminants. Environ Health Perspect 2001 Dec; 109 (12): 1291 37 Cernichiari E, Brewer R, Myers GJ, Marsh DO, Lapham LW, Cox C, Shamlaye CF, Berlin M, Davidson PW, Clarkson TW. Monitoring methylmercury during pregnancy: maternal hair predicts fetal brain exposure. Neurotoxicology 1995; 16: 705–710. 38 Amin-Zaki L, Elhassani S, Majeed MA, Clarkson TW, Doherty RA, Greenwood M. Intra-uterine methyl mercury poisoning in Iraq. Pediatrics 1974; 54 (5): 587–595. 39 Ballatori N, Clarkson TW. Biliary secretion of glutathione and glutathione-metal complexes. Fund Appl Toxicol 1985; 5: 816–831. 40 Kerper LE, Ballatori N, Clarkson TW. Methylmercury transport across the blood-brain barrier by an amino acid carrier. Am J Physiol 1992; 267: R761–765. 41 Dutczak WJ, Ballatori N. ϒ-glutaml transferase dependent biliary hepatic recycling of methyl mercury in the guinea pig. J Pharmacol Exp Ther 1992; 262: 619–623. 42 Dutczak WJ, Ballatori N. Transport of the glutathione-methyl mercury complex across liver canalicular membranes on reduced glutathione carriers. J Biol Chem 1994; 269: 9746–9751. 43 Smith JC, Allen PV, Turner MD, Most B, Fisher HL, Hall LL. The kinetics of intravenously administered methyl mercury in man. Toxicol Appl Pharmacol 1994; 128: 251–256. 44 Magos L. Three cases of methylmercury intoxication which correct diagnosis. Arch Toxicol 1998; 72: 701–705. 45 Nierenberg DW, Nordgren RE, Chang MB, Siegler W, Blayney MG, Hochberg F, Toribara TY, Cernichiari E, Clarkson T. Delayed cerebellar disease and death after accidental exposure to dimethyl mercury. N Engl J Med 1998; 338: 1672–1675. 46 Syversen TLM. Changes in protein and RNA synthesis in rat brain after a single dose of methyl mercury. Toxicol Lett 1982; 10: 31–34. 47 Jacobs JM, Carmicheal N, Cavavagh JB. Ultrasructural changes in the nervous system of rabbits poisoned with methyl mercury. Toxicol Appl Pharmacol 1977; 39: 249–261. 48 Sarafian TA, Bredesen DE, Verity MA. Cellular resistance to methyl mercury. Neurotox 1996; 17: 27–36. 49 Miura K, Clarkson TW. Reduced methylmecury accumulation in a methylmercury – resistant rat pheochromocytoma PC12 cell line. Toxicol Appl Pharmacol 1993; 118: 39–45. 50 Davis LE, Kornfeld M, Mooney HS, Fiedler KJ, HaalandKY, Orrison WW, Cernchiari E, Clarkson TW. Methyl mercury poisoning: long term clinical, radiological, toxicological and pathological studies. Ann Neurol 1994; 35: 680–688. 51 Charleston JS, Body RL, Bolender RP, Mottet NK, Vahter ME, Burbacher TM. Changes in the number of astrocytes and microglia in the thalamus of the monkey Macaca fascicularis following long-term subclinical methylmercury exposure. Neurotoxicology 1996; 17: 127–138. 52 Magos L, Brown AW, Sparrow S, Bailey E, Snowden RE, Skipp WR. The comparative toxicology of ethyl- and methyl mercury. Arch Toxicol 1985; 57: 260–267. 53 Takeuchi T. Pathology of Minamata disease: the effect of methyl mercury on interuterine life of human beings. Pediatrician 1977; 6: 69–87. 54 Marsh DO, Clarkson TW, Cox C, Myers GJ, Amin-Zaki L, Al-Tikriti S. Fetal methylmercury poisoning: relationship between concentration in single strands of maternal hair and child effects. Arch Neurol 1987; 44: 1017–1022. 55 Cox C, Clarkson TW, Marsh DO, Amin-Zaki L, Al-Tikriti S, Myers G. Dose-response analysis of infants prenatally exposed to methyl mercury: an application of a single compartment model to single-strand hair analysis. Environ Res 1989; 49: 318–332. 56 Swedish Expert Group. Methylmercury in fish. A toxicological-epidemiological evaluation of risks. Nord Hyg Tidskr 1971; 4 (suppl): 19–364. 57 Watanabe C, Satoh H. Evolution of our understanding of methylmercury as a health threat. Environ Health Perspect 1996; 104: 367–379. 58 Moriyama H, Takizawa. Assessing low-dose effects on children exposed in utero to methylmercury—Protocol for on-the-spot re-inspection for Minamata and Niigata data at early stage. In: Y Takizawa, M Oame, editors. Understanding of Minamata disease: methlymercury poisoning in Minamata and Niigata, Japan. Tokyo: Japan Public Health Association. 59 McKeown-Eyssen GE, Ruedy J, Neims A. Methylmercury exposure in northern Quebec. II. Neurological findings in children. Am J Epidemiol 1983; 118: 470–479. 60 Kjellstrom T, Kennedy P, Wallis S, Mantell C. Phyical and mental development of children with prenatal exposure to mercury from fish. Stage 1. Preliminary tests at age 4. Solna: National Swedish Environmental Board 96 pp (Report No. 3080); 1986. 61 Kjellstrom T, Kennedy P, Wallis S, Stewart A, Friberg L, Lind B, Wutherspoon P, Mantell C. Physical and mental development of children with prenatal exposure to mercury from fish. Stage 2. Interviews and psychological tests at age 6. Solna: National Swedish Environmental Board (Report No. 3642); 1989. 112 p. 62 Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sorensen N, Dahl R, Jorgensen PJ. Cognitive deficit in 7 year old children with prenatal exposure to methyl mercury. Neurotoxicol Teratol 1997; 6: 417–428. 63 Davidson PW, Kost J, Myers GJ, Cox C, Clarkson TW, Shamlaye CF. and neurodevelopment: reanalysis of the Seychelles Child Development Study outcomes at 66 months of age. JAMA 2001; 285: 1291–1293. 64 Choi BH, Lapham LW, Amin-Zaki L, Saleem T. Abnormal neuronal migration, deranged cerebellar cortical organization, and diffuse white matter astrocytosis of human fetal brain. A major effect of methyl mercury poisoning in utero. J Neuropathol Neurol 1978; 37: 719–733. 65 Miura K, Imura N. Mechanism of methyl mercury cyto-toxicity. Crit Rev Toxicol 1987; 18: 161–188. 66 Rodier PM, Ashner M, Sager PR. Mitotic arrest in the developing CNS after prenatal exposure to methyl mercury. Neurobehav Toxicol Teratol 1984; 6: 379–385. 67 Philbert MA, Billingsley ML, Reuhl KR. Mechanisms of injury in the central nervous system. Toxicol Pathol 2000; 28: 43–53. 68 AAP and USPHS. Joint statement of the American Academy of Pediatrics (AAP) and the United States Public Health Service (USPHS). Pediatrics 1999; 104: 568–569. 69 Ball LK, Ball R, Pratt RD. An assessment of Thimerosal use in childhood vaccines. Pediatrics 2001; 107: 1147–1154. 70 Pless R, Risher JF. Mercury, infant neurodevelopment, and vaccination. J Pediatr 2000; 136: 571–573. 71 Seal JB, Daum RS. What happened to Primum Non Nocere. Pediatrics 2001; 107: 1177–1178. 72 Bernard S, Enayati A, Redwood L, Roger H, Binstock T. Autism: a Novel form of Mercury Poisoning. Cranford, NJ: ARAC Research; 2000. p 1–11. 73 Al-Damluji S. Mercurial poisoning with the fungicide granosan M. J Faculty Med (Baghdad) 1962; 4: 82–103. 74 Jalili MA, Abbasi AH. Poisoning by ethyl mercury toluene sulfananilade. Br J Ind Med 1961; 18: 303–308. 75 Zhang J. Clinical observations in ethyl mercury chloride poisoning. Am J Ind Med 1984; 5: 251–258. 76 Axton JHM. Six cases of poisoning after a parenteral organic mercurial compound (Merthiolate). Postgrad Med J 1972; 48: 417–421. 77 Rohyans J, Walson PD, Wood GA, MacDonald WA. Mercury toxicity following merthiolate ear irrigations. Pediatrics 1984; 104: 311–313. 78 Pfab R, Muckter H, Roider G, Zilker T. Clinical course of severe poisoning with Thimerosal. Clin Toxicol 1996; 34: 453–460. 79 Fagan DG, Pritchard JS, Clarkson TW, Greenwood MR. Organ mercury levels in infants with omphaloceles treated with organic mercurial antiseptic. Arch Dis Child 1977; 52: 962–964. 80 Matheson DS, Clarkson TW, Gelfand EW. Mercury toxicity (acrodynia) induced by long-term injection of gamma globulin. J Pediatr 1980; 97: 153–155. 81 Zemtsov A, Bolton GG. Thimerosal-induced bullous contact dermatitis. Contact Dermatitis 1994; 30: 57. 82 Zenorala P, Gimma A, Lomuto M. Systemic contact dermatitis from Thimerosal. Contact Dermatits 1995; 32: 107–108. 83 Cox NH, Forsyth A. Thimerosal and vaccination reactions. Contact Dermatitis 1988; 18: 229–233. 84 McKenna KE. Eczematous reaction to hepatitis B vaccine. Contact Dermatitis 1999; 40: 158–159. 85 EPA. Mercury report to Congress, Office of Air Quality and Standards, Washington, DC: US Environmental Protection Agency; 1997. 86 U.S. EPA Methylmercury (MeHg) Iris Summary. 2002. http://www.epa.gov/iris/subst/0073.htm 87 Stajich GV, Lopez GP, Harry SW, Sexson WR. Iatrogenic exposure to mercury after hepatitis B vaccination in pre-term infants. J Pediatr 2000; 136: 679–681. 88 Pichichero ME, Cernichiari E, Lopreiato J, Treanor J. Mercury concentrations and metabolism in infants receiving vaccines containing thimerosal: a descriptive study. Lancet 2002; 360: 1737–1741. 89 Magos L. Review on the Toxicity of ethyl mercury including its presence as a preservative in biological and pharmaceutical preparations. J Appl Toxicol 2001; 21: 1–5. 90 Wantke F, Demmer CM, Gotz M, Jarisch RR. Contact dermatitis from thimerosal. 2 years experience with ethylmercuric chloride in patach testing thimerosal-sensitive patients. Contact Dermatitis 1994; 30: 115–117. 91 Santucci B, Cannistraci C, Cristaudo A, Camera E, Picardo M. Thimerosal positivities: the role of organomercury alkyl compounds. Contact Dermatitis 1998; 38: 325–328. 92 Goncalo M, Figueiredo A, Goncalo S. Contact Dermatitis 1996; 34: 201–203. 93 WHO. Recommendations from the Strategic Advisory Group of Experts. Weekly Epidemiol Rec 2002; 77: 305–316. Citing Literature Volume16, Issue42003Pages 321-343 ReferencesRelatedInformation