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Elevation of serum group II phospholipase A2 levels in patients with advanced cancer

1994; Elsevier BV; Volume: 228; Issue: 2 Linguagem: Inglês

10.1016/0009-8981(94)90280-1

1873-3492

Shinichi Yamashita, Michio Ogawa, Kiyoshi Sakamoto, Toshihiko Abe, Hirofumi Arakawa, Jun‐ichi Yamashita,

Protein Kinase Regulation and GTPase Signaling

To investigate the role of group II phospholipase A2 (M-PLA2) in cancer, we examined M-PLA2 serum levels in 170 pre-operative patients with various cancers and found elevated levels in 49% of them. M-PLA2 serum levels were significantly higher in patients with tumor stages T2-4, N1, M1 and stages II to IV than in T1, N0, M0 and stage I tumors, respectively. In all nine post-operative patients tested, M-PLA2 decreased 14 days after tumor resection and reduced to normal levels in 4 patients. Six of 16 carcinoma cell lines (37.5%) spontaneously secreted M-PLA2 into the culture supernatant despite the absence of IL-6 and IL-1 in 5 of the 6 lines. These results demonstrate that M-PLA2 produced by cancer cells may contribute, at least in part, to the elevation of serum M-PLA2 levels observed in cancer patients.