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Direct Palladium-Catalyzed Alkynylation of N-Fused Heterocycles

2007; American Chemical Society; Volume: 129; Issue: 25 Linguagem: Inglês

10.1021/ja072718l

1943-2984

И. В. Серегин, Victoria Ryabova, Vladimir Gevorgyan,

Synthesis and Catalytic Reactions

The first example of direct C−H alkynylation of electron-rich heteroaromatics has been demonstrated. This mild, simple, and general method allows for the efficient synthesis of diverse alkynyl heterocycles. Kinetic isotope effect studies support an electrophilic substitution pathway for this transformation.