Churchill, a Zinc Finger Transcriptional Activator, Regulates the Transition between Gastrulation and Neurulation
2003; Cell Press; Volume: 115; Issue: 5 Linguagem: Inglês
10.1016/s0092-8674(03)00927-9
ISSN1097-4172
AutoresGuojun Sheng, Mario dos Reis, Claudio D. Stern,
Tópico(s)Cancer-related molecular mechanisms research
ResumoGastrulation generates mesoderm and endoderm from embryonic epiblast; soon after, the neural plate is established within the epiblast-both events require FGF signaling. We describe a zinc finger transcriptional activator, Churchill (ChCh), which acts as a switch between different roles of FGF. FGF induces ChCh slowly; this activates Smad-interacting-protein-1 (Sip1), which blocks further induction of the mesoderm markers brachyury and Tbx6L by FGF. ChCh is first expressed as cells stop migrating through the primitive streak, and we show that it regulates cell ingression. We propose a simple mechanism by which FGF sensitizes cells to BMP signals. These results reveal that neural induction requires cessation of mesoderm formation at the midline in addition to the decision between epidermis and neural plate.
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