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Inhibition of lysine biosynthesis: an evolving antibiotic strategy

2007; Royal Society of Chemistry; Volume: 3; Issue: 7 Linguagem: Inglês

10.1039/b705624a

1742-206X

Craig A. Hutton, Matthew A. Perugini, Juliet A. Gerrard,

Antimicrobial Peptides and Activities

Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides lysine for protein synthesis and both lysine and meso-diaminopimelate for construction of the bacterial peptidoglycancell wall. In this Highlight article we review recent advances in the validation of antibiotic targets, studies of the enzymes of the lysine biosynthetic pathway and development of inhibitors of these enzymes.