Aromatic retinoids (part 2): A short and convenient route to 5-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-2-furan and -2-thiophene carboxylic acids.
1988; Elsevier BV; Volume: 29; Issue: 35 Linguagem: Inglês
10.1016/s0040-4039(00)80508-0
ISSN1873-3581
AutoresJacques Eustache, Jean‐Michel Bernardon, Braham Shroot,
Tópico(s)Synthesis and Biological Evaluation
ResumoA convenient three step synthetic route starting from readily available materials was used for the synthesis of novel 5-(2-tetrahydroanthracenyl)-2-furan and -2-thiophenecarboxylic acid derivatives. The main features of the sequence are a Heck reaction between a substituted styrene derivative and bromo heterocycles, followed by high yield electrophilic cyclisation/aromatization of the intermediate thus obtained to afford the desired compounds.
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