G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy
2014; National Academy of Sciences; Volume: 111; Issue: 44 Linguagem: Inglês
10.1073/pnas.1417898111
ISSN1091-6490
AutoresJames P. White, Christiane D. Wrann, Rajesh R. Rao, G Anil Kumar, Mark P. Jedrychowski, Jae‐Sung You, Vicente Martínez-Redondo, Steven P. Gygi, Jorge L. Ruas, Troy A. Hornberger, Zhidan Wu, David J. Glass, Xianhua Piao, Bruce M. Spiegelman,
Tópico(s)Muscle metabolism and nutrition
ResumoSignificance The work reported in this paper describes a previously unknown signaling pathway in skeletal muscle acting through G protein-coupled receptor 56-Galpha12/13. This discovery elucidates a previously unknown mechanism of muscle anabolism and gives another target of investigation for therapies against the loss of muscle mass seen with aging and various wasting diseases.
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