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Age at menarche is not an independent risk factor for high-risk human papillomavirus infections and cervical intraepithelial neoplasia

2008; SAGE Publishing; Volume: 19; Issue: 1 Linguagem: Inglês

10.1258/ijsa.2007.007042

1758-1052

Karí Syrjänen, Irena Shabalova, Nicolay Petrovichev, В. П. Козаченко, Tatjana Zakharova, Julia Pajanidi, Jurij Podistov, G. Yu. Chemeris, Larisa G. Sozaeva, Elena Lipova, Irena Tsidaeva, Olga Ivanchenko, Ala Pshepurko, Sergej Zakharenko, Raisa Nerovjna, Ludmila Kljukina, Oksana Erokhina, Marina Branovskaja, Maritta Ņikitina, Valerija Grunberga, Alexandr Grunberg, Anna Juschenko, Rosa Santopietro, Marcella Cintorino, Piero Tosi, Stina Syrjänen,

Reproductive tract infections research

Data are controversial as to the role of menarche age as a risk factor of high-risk human papillomavirus (HR-HPV) infections. The objective of this study was to analyse the risk estimates for age at menarche as determinant of cervical intraepithelial neoplasia (CIN) and HR-HPV infections. A cohort of 3187 women were stratified into three groups according to their age at menarche: (i) women 15 years of age. These groups were analysed for predictors of (a) HR-HPV, (b) high-grade CIN and (c) outcome of HR-HPV and cytological abnormalities during prospective follow-up. All the three groups had identical prevalence of HR-HPV, Papanicolaou smear abnormalities and CIN grades. In contrast to menarche age itself, the time from menarche to the first intercourse (TMI), to the first pregnancy (TMP) and to the first delivery (TMD) were all significant (P = 0.0001) predictors of HR-HPV (but not CIN2) in univariate analysis, but lost their significance in a multivariate model. Outcome of cervical disease and HR-HPV infection was unrelated to menarche age, the latter and the three intervals being not predictors of CIN2 in a multivariate model. In conclusion, age at menarche and the intervals between menarche and (i) onset of sexual activity, (ii) first pregnancy and iii) first delivery, are not independent predictors of HR-HPV infections and CIN2 in multivariate analysis.