Portal de Periódicos da CAPES

Chemerin regulates β-cell function in mice

2011; Nature Portfolio; Volume: 1; Issue: 1 Linguagem: Inglês

10.1038/srep00123

2045-2322

Michiko Takahashi, Yasuhiko Okimura, Genzo Iguchi, Hitoshi Nishizawa, Masaaki Yamamoto, Kentaro Suda, Riko Kitazawa, Wakako Fujimoto, Kenichi Takahashi, Fyodor N. Zolotaryov, Kyoung Su Hong, Hiroshi Kiyonari, Takaya Abe, Hidesuke Kaji, Sohei Kitazawa, Masato Kasuga, Kazuo Chihara, Yutaka Takahashi,

Regulation of Appetite and Obesity

Although various function of chemerin have been suggested, its physiological role remains to be elucidated. Here we show that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue. The glucose intolerance was mainly due to increased hepatic glucose production and impaired insulin secretion. Chemerin and its receptor ChemR23 were expressed in β-cell. Studies using isolated islets and perfused pancreas revealed impaired glucose-dependent insulin secretion (GSIS) in chemerin-deficient mice. Conversely, chemerin transgenic mice revealed enhanced GSIS and improved glucose tolerance. Expression of MafA, a pivotal transcriptional factor for β-cell function, was downregulated in chemerin-deficient islets and a chemerin-ablated β-cell line and rescue of MafA expression restored GSIS, indicating that chemerin regulates β-cell function via maintaining MafA expression. These results indicate that chemerin regulates β-cell function and plays an important role in glucose homeostasis in a tissue-dependent manner.