Polysytyrene-supported synthesis by the phosphite triester approach: An alternative for the large scale synthesis of small oligodeoxyribonucleotides.
1990; Elsevier BV; Volume: 31; Issue: 43 Linguagem: Inglês
10.1016/s0040-4039(00)97032-1
ISSN1873-3581
AutoresFrancesc Bardella, Ernest Giralt, Enrique Pedroso,
Tópico(s)Click Chemistry and Applications
ResumoThe large scale synthesis of two octadeoxyribonuclcotides has been successfully accomplished on polystyrene by the phosphite triester approach. Employing moderate excesses but high concentrations of phosphoramidites, the coupling yields are similar to those obtained in standard small scale syntheses.
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