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Genome-wide association studies: a primer

2009; Cambridge University Press; Volume: 40; Issue: 7 Linguagem: Inglês

10.1017/s0033291709991723

1469-8978

Aiden Corvin, Nicholas Craddock, P. F. Sullivan,

Epigenetics and DNA Methylation

There have been nearly 400 genome-wide association studies (GWAS) published since 2005. The GWAS approach has been exceptionally successful in identifying common genetic variants that predispose to a variety of complex human diseases and biochemical and anthropometric traits. Although this approach is relatively new, there are many excellent reviews of different aspects of the GWAS method. Here, we provide a primer, an annotated overview of the GWAS method with particular reference to psychiatric genetics. We dissect the GWAS methodology into its components and provide a brief description with citations and links to reviews that cover the topic in detail.