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Five Genome Sequences of Subspecies B1 Human Adenoviruses Associated with Acute Respiratory Disease

2011; American Society for Microbiology; Volume: 86; Issue: 1 Linguagem: Inglês

10.1128/jvi.06593-11

1098-5514

Shoaleh Dehghan, Elizabeth B. Liu, Jason Seto, Sarah Torres, Nolan Ryan Hudson, Adriana E. Kajon, David Metzgar, David W. Dyer, James Chodosh, Morris S. Jones, Donald Seto,

Viral Infections and Immunology Research

ABSTRACT Five genomes of human subspecies B1 adenoviruses isolated from cases of acute respiratory disease have been sequenced and archived for reference. These include representatives of two prevalent genomic variants of HAdV-7, i.e., HAdV-7h and HAdV-7d2. The other three are HAdV-3/16, HAdV-16 strain E26, and HAdV-3+7 strain Takeuchi. All are recombinant genomes. Genomics and bioinformatics provide detailed views into the genetic makeup of these pathogens and insight into their molecular evolution. Retrospective characterization of particularly problematic older pathogens such as HAdV-7h (1987) and intriguing isolates such as HAdV-3+7 strain Takeuchi (1958) may provide clues to their phenotypes and serology and may suggest protocols for prevention and treatment.