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Coumarins Isolated from Angelica g igas Inhibit Acetylcholinesterase: Structure−Activity Relationships

2001; American Chemical Society; Volume: 64; Issue: 5 Linguagem: Inglês

10.1021/np000441w

1520-6025

So Young Kang, Ki Yong Lee, Sang Hyun Sung, Mi Jung Park, Young Choong Kim,

Plant chemical constituents analysis

Acetylcholinesterase (AChE) inhibitory activity−guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.