Inactivation of Herpes Simplex Viruses by Nonionic Surfactants
1978; American Society for Microbiology; Volume: 13; Issue: 4 Linguagem: Inglês
10.1128/aac.13.4.686
ISSN1098-6596
AutoresS Asculai, Margaret T. Weis, Martha W. Rancourt, A. B. Kupferberg,
Tópico(s)Advancements in Transdermal Drug Delivery
ResumoNonionic surface-active agents possessing ether or amide linkages between the hydrophillic and hydrophobic portions of the molecule rapidly inactivated the infectivity of herpes simplex viruses. The activity stemmed from the ability of nonionic surfactants to dissolve lipid-containing membranes. This was confirmed by observing surfactant destruction of mammalian cell plasma membranes and herpes simplex virus envelopes. Proprietary vaginal contraceptive formulations containing nonionic surfactants also inactivated herpes simplex virus infectivity. This observation suggests that nonionic surfactants in appropriate formulation could effectively prevent herpes simplex virus transmission.
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