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Making new contacts: the mTOR network in metabolism and signalling crosstalk

2014; Nature Portfolio; Volume: 15; Issue: 3 Linguagem: Inglês

10.1038/nrm3757

1471-0080

Mitsugu Shimobayashi, Michael N. Hall,

Protein Kinase Regulation and GTPase Signaling

Our understanding of the downstream effectors and upstream regulators of target of rapamycin (TOR) signalling continues to grow. In particular, recent global 'omics' studies have revealed physiological roles of mammalian TOR (mTOR) in protein, nucleotide and lipid synthesis, and other studies showed that Hippo, WNT and Notch signalling are novel regulators of mTOR. More than 20 years after its discovery, our understanding of target of rapamycin (TOR) signalling continues to grow. Recent global 'omics' studies have revealed physiological roles of mammalian TOR (mTOR) in protein, nucleotide and lipid synthesis. Furthermore, emerging evidence provides new insight into the control of mTOR by other pathways such as Hippo, WNT and Notch signalling. Together, this progress has expanded the list of downstream effectors and upstream regulators of mTOR signalling.