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Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy

2014; Elsevier BV; Volume: 276; Issue: 1-2 Linguagem: Inglês

10.1016/j.jneuroim.2014.09.001

1872-8421

Francesca Notturno, Tiziana Di Febo, Nobuhiro Yuki, Blanca M. Fernandez Rodriguez, Davide Corti, Eduardo Nobile‐Orazio, M. Carpo, Angelo De Lauretis, Antonino Uncini,

Nerve injury and regeneration

We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.