Metabolism of Xenobiotics in the Nasal Olfactory Mucosa: Implications for Local Toxicity
1993; Wiley; Volume: 72; Issue: s2 Linguagem: Inglês
10.1111/j.1600-0773.1993.tb01701.x
ISSN1600-0773
Autores Tópico(s)Biochemical Analysis and Sensing Techniques
ResumoPharmacology & ToxicologyVolume 72, Issue s2 p. 50-52 Metabolism of Xenobiotics in the Nasal Olfactory Mucosa: Implications for Local Toxicity Eva B. Brittebo, Eva B. Brittebo Department of Pharmacology, University of Lund, Sölvegatan 10, S-223 62 Lund, SwedenSearch for more papers by this author Eva B. Brittebo, Eva B. Brittebo Department of Pharmacology, University of Lund, Sölvegatan 10, S-223 62 Lund, SwedenSearch for more papers by this author First published: March 1993 https://doi.org/10.1111/j.1600-0773.1993.tb01701.xCitations: 13AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References Adams, D.R., A. M. Jones, C. G. Plopper C. J. Serabjit-Singh & R. M. Philpot: Distribution of cytochrome P-450 monooxygenase enzymes in the nasal mucosa of hamster and rat. Am J Anat. 1991, 190, 291–298. Bogdanffy, M.S., H. W. Randall & K. T. Morgan: Biochemical quantitation and histochemical localization of carboxylesterase in the nasal passages of the Fisher-344 rat and B6C3F1 mouse. Toxicol. Appl. Pharmacol. 1987, 88, 183–194. Brandt, I., E. B. Brittebo, V. J. Feil & J. E. Bakke: Irreversible bin-ding and toxicity of the herbicide dichlobenil (2,6 dichlorobenzonitrile) in the olfactory mucosa of mice. Toxicol. Appl. Pharmacol. 1990, 103, 491–501. Brittebo, E.B.: N-Demethylation of aminopyrine by the nasal mucosa in mice and rats. Acta Pharmacol. Toxicol. 1982a, 51, 227–232. Brittebo, E.B.: Metabolism of progesterone by the nasal mucosa in mice and rats. Acta Pharmacol. Toxicol. 1982b, 51, 441–445. Brittebo, E.B., A. Castonguay, K. Furuya & S.S. Hecht: Metabolism of tobacco-specific nitrosamines by cultured rat nasal mucosa. Cancer Research 1983, 43, 4343–4348. Brittebo, E.B.: Metabolic activation of phenaceun in rat nasal mucosa: Dose dependent binding to the glands of Bowman. Cancer Res. 1987, 47, 1449–1456. Brittebo, E.B., C. Eriksson, & I. Brandt: Effects of glutamione-modulating agents on the covalent binding and toxicity of dichlobenil in the mouse olfactory mucosa. Toxicol Appl Pharmacol,. 1992, 114, 31–40. Brittebo, E.B., C. Eriksson, V. J. Feil & J. Bakke, & I. Brandt: Toxicity of 2,6-dichlorothiobenzamide and 2,6-dichlorobenzamide in the olfactory nasal mucosa of mice. Fund. Appl. Pharmacol. 1991, 17, 92–102. Brittebo, E.B, B. Löfberg & H. Tjäive.: Sites of metabolism of N-nitrosodiethylamine in mice. Chem.-Biol. Interactions 1981. 34, 209–221. Brittebo, E. B. & J. J. Rafter.: Steroid metabolism by rat nasal mucosa: Studies on progesterone and testosterone. J. Steroid Biochem. 1984. 20, 1147–1151. Buck, L. & R. Axel: A novel multigene family may encode odorant receptors: A molecular basis for odor recognition. Cell 1991, 65, 175–187. Ding, X. & M. J. Coon: Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes. Biochemistry 1988, 27, 8330–8337. Eriksson, C. & E. B. Brittebo.: Metabolic activation of the herbicide dichlobenil in the olfactory mucosa. Chem. Biol. Interact. 1991, 79, 165–177. Foster, J. R., C. R. Elcombe, A. L. Boobis, D. S. Davies, D. Sesardic, J. McQuad, R. T. Robson, C. Hay ward & E. A. Lock.: Immunocytochemical localization of cytochrome P-450 in hepatic and extra-hepatic tissues of the rat with a monoclonal antibody against cytochrome P-450c. Biochem Pharmacol 1986. 35, 4543–4554. Frisch, D.: Ultrastructure of the mouse olfactory mucosa. Am.J. Anat. 1967, 121, 87–120. Graziadei, P. P. C.: Cell dynamics in the olfactory mucosa. Tissue Cell 1973, 5, 113–131. Hadley, W. M. & A.R. Dahl: Cytochrome P-450 dependent monooxygenase activity in rat nasal epithelial membranes. Toxico Lett. 1982, 10, 417–422. Larsson, P. & H. Tjälve: Binding of aflatoxin B1 metabolites in extrahepatic tissues in fetal and infant and in adult mice with depleted glutathione levels. Cancer Res 1992, 52, 1267–1277. Lazard, D., N. Tal, M. Rubinstein, M. Khen, D. Lancet & K. Zupko: Identification and biochemical analysis of novel olfactory specific cytochrome P450 IIA and UDP-glucuronosyl transferase. Biochemistry 1990, 29, 7433–7440. Mitchell, J. R., D. J. Jollow, W. Z. Potter, J. R. Gilette & B. B. Brodie: Acetaminophen-induced hepatic necrosis. IV Protective role of glutathione. J Pharmacol. Exp Ther. 1973, 187, 211–217. Nef, P., J. Heldman, D. Lazard, T. Margalit, M. Jaye, I. Hanukoglu & D. Lancet: Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception. J Biol Chem 1989, 264, 6780–6785. Reed, C. J., E. A. Lock & F DeMatteis: Olfactory cytochrome P-450. Studies with suicide substrates of the haemoprotein. Biochem J 1988, 253, 569–576. Sabourin, P. J., R. E. Tynes, R. N. Philpot, S. Winquist & A.R. Dahl: Distribution of microsomal monooxygenases in the rabbit respiratory tract. Drug. Metab. Disp. 1988, 16, 557–562. Voigt, J. M., F.P. Guengerich & J. Baron: Localization of acytochrome P-450isozyme (cytochrome P-450 PB-B)and a NADPH cytochrome P-450 reductase in rat nasal mucosa. Cancer Lett 1985, 27, 241–247. Zupko, K., Y. Poria & D. Lancet: Immunolocalization of cytochrome P450olfl and P450olf2 in rat olfactory mucosa. Eur. J. Biochem. 1991, 47, 51–58. Citing Literature Volume72, Issues2March 1993Pages 50-52 ReferencesRelatedInformation
Referência(s)