Genetic Variation and Human Disease: Principles and Evolutionary Approaches
1997; Elsevier BV; Volume: 60; Issue: 6 Linguagem: Inglês
10.1016/s0002-9297(07)64257-8
ISSN1537-6605
Autores Tópico(s)Nutrition, Genetics, and Disease
ResumoPreface Part I. Genes and Their Expression: 1. What is a gene? 2. The logic of the genome 3. Concepts of frequency and association in populations 4. Genes and phenotypes in populations Part II. Introduction to Genetic Epidemiology: Inference from Observational Data: 5. Segregation analysis: discrete traits in families 6. Segregation analysis: quantitative traits in families 7. Linkage analysis: finding and mapping genes for qualitative traits 8. Linkage analysis: finding and mapping genes for quantitative traits Part III. Evolution: The Time Dimension in Populations: 9. Genes over time and space 10. Reconstructing history: the footprints of evolution 11. Evolution generates heterogeneity Part IV. Modification of the Inherited Genotype: The Time Dimension in Individuals: 12. Phenotype amplification by the environment 13. Infectious disease: the response to biological challenge 14. Variation within the inherited genotype 15. Cancer and ageing: a microcosm of evolution during life Afterwords: towards a unified general model Conclusion Notes References Index.
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