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Efficacy of Rifampin-Moxifloxacin-Metronidazole Combination Therapy in Hidradenitis Suppurativa

2010; Karger Publishers; Volume: 222; Issue: 1 Linguagem: Inglês

10.1159/000321716

1421-9832

Olivier Join‐Lambert, H. Coignard, Jean-Philippe Jaı̈s, Hélène Guet‐Revillet, S. Poirée, Sylvie Fraitag, Vincent Jullien, Florence Ribadeau-Dumas, Jacques Thèze, Anne Le Flèche‐Matéos, Sylvie Behillil, Anne Le Flèche‐Matéos, Patrick Berche, Paul‐Henri Consigny, Olivier Lortholary, Xavier Nassif, Aude Nassif,

Colorectal and Anal Carcinomas

Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments.To assess the efficacy and safety of a combination of oral rifampin, moxifloxacin and metronidazole in long-lasting refractory HS.We retrospectively studied 28 consecutive HS patients including 6, 10 and 12 Hurley stage 1, 2 and 3 patients, respectively. Complete remission, defined as a clearance of all inflammatory lesions including hypertrophic scars, was the main outcome criterion of the study.Complete remission was obtained in 16 patients, including 6/6, 8/10 and 2/12 patients with Hurley stage 1, 2 and 3, respectively (p=0.0004). The median duration of treatment to obtain complete remission was 2.4 (range 0.9-6.5) and 3.8 months (range 1.6-7.4) in stage 1 and 2 patients, respectively, and 6.2 and 12 months in the 2 stage 3 patients. Main adverse events of the treatments were gastrointestinal disorders (64% of patients) and vaginal candidiasis (35% of females). Reversible tendinopathy and hepatitis occurred in 4 and 1 patient, respectively.Complete remission of refractory HS can be obtained using broad-spectrum antibiotics and Hurley staging is a prognostic factor of response to the treatment.