ZrCl 4 -Mediated Regio- and Chemoselective Friedel–Crafts Acylation of Indole
2011; American Chemical Society; Volume: 76; Issue: 11 Linguagem: Inglês
10.1021/jo200561f
ISSN1520-6904
AutoresSankar K. Guchhait, Maneesh Kashyap, Harshad Kamble,
Tópico(s)Chemical Synthesis and Analysis
ResumoAn efficient method for regio- and chemoselective Friedel-Crafts acylation of indole using acyl chlorides in the presence of ZrCl(4) has been discovered. It minimizes/eliminates common competing reactions that occur due to high and multiatom-nucleophilic character of indole. In this method, a wide range of aroyl, heteroaroyl alkenoyl, and alkanoyl chlorides undergo smooth acylation with various indoles without NH protection and afford 3-acylindoles in good to high yields.
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