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Octreotide reduces the kinetic index, proliferating cell nuclear antigen–maximum proliferative index, in patients with colorectal cancer

1995; Wiley; Volume: 76; Issue: 4 Linguagem: Inglês

10.1002/1097-0142(19950815)76

1097-0142

G. J. Stewart, Jennie Connor, J A Lawson, Angelo P Preketes, Julie King, David L. Morris,

Genetic factors in colorectal cancer

CancerVolume 76, Issue 4 p. 572-578 Original ArticleFree Access Octreotide reduces the kinetic index, proliferating cell nuclear antigen–maximum proliferative index, in patients with colorectal cancer† Graham J. Stewart M.B.B.S., Graham J. Stewart M.B.B.S. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaSearch for more papers by this authorJennie L. Connor M.B., Ch.B., Jennie L. Connor M.B., Ch.B. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaSearch for more papers by this authorJane A. Lawson B.Sc., M.Sc., Jane A. Lawson B.Sc., M.Sc. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaSearch for more papers by this authorAngelo Preketes M.B.B.S., Angelo Preketes M.B.B.S. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaSearch for more papers by this authorJulie King B.A., Julie King B.A. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaSearch for more papers by this authorDavid L. Morris M.B., Ch.B., F.R.C.S., M.D., Ph.D., F.R.A.C.S., Corresponding Author David L. Morris M.B., Ch.B., F.R.C.S., M.D., Ph.D., F.R.A.C.S. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaUNSW Department of Surgery, The St. George Hospital, Kogarah, Sydney NSW 2217, Australia===Search for more papers by this author Graham J. Stewart M.B.B.S., Graham J. Stewart M.B.B.S. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaSearch for more papers by this authorJennie L. Connor M.B., Ch.B., Jennie L. Connor M.B., Ch.B. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaSearch for more papers by this authorJane A. Lawson B.Sc., M.Sc., Jane A. Lawson B.Sc., M.Sc. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaSearch for more papers by this authorAngelo Preketes M.B.B.S., Angelo Preketes M.B.B.S. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaSearch for more papers by this authorJulie King B.A., Julie King B.A. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaSearch for more papers by this authorDavid L. Morris M.B., Ch.B., F.R.C.S., M.D., Ph.D., F.R.A.C.S., Corresponding Author David L. Morris M.B., Ch.B., F.R.C.S., M.D., Ph.D., F.R.A.C.S. University of New South Wales Department of Surgery, The St. George Hospital, Kogarah, Sydney, AustraliaUNSW Department of Surgery, The St. George Hospital, Kogarah, Sydney NSW 2217, Australia===Search for more papers by this author First published: 15 August 1995 https://doi.org/10.1002/1097-0142(19950815)76:4 3.0.CO;2-0Citations: 9 † Presented in part at the 40th Annual General and Scientific Meeting, Surgical Research Society of Australasia, St. Vincent's Clinic, Sydney, Australia, August 25-27, 1994 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Background. Somatostatin has been shown to inhibit in vitro and xenograft growth of human colon cancer. The kinetic index, proliferating cell nuclear antigen (PCNA), has previously been used to measure the effects of manipulation of growth of normal rectal epithelium. Methods. Twenty-five patients with distal colorectal cancer were considered for entry in a presurgical study of Sandostatin (Sandoz, East Hanover, NJ) 1 mg every 8 hours. Biopsies were performed pretreatment, during treatment (14 days), and day of surgical resection (2 days off treatment). A control series of 16 patients underwent endoscopic and subsequent surgical biopsy. A kinetic index was created called PCNA-maximum proliferative index (PCNA–MPI), which was reproducible within one biopsy and between two separate biopsies. Multiple biopsies were taken from the growing edge of tumors, the most cellular and best-stained fields selected, and the highest 6 of 10 separate counted fields were used to produce PCNA-MPI. Results. A significant decline in PCNA-MPI was observed in 6 of the 10 treated patients for whom all three biopsies were available, followed by a significant elevation on withdrawal of treatment. Changes in PCNA-MPI in the control group were less frequent and smaller. Conclusions. Sandostatin causes a reduction in PCNA-MPI in patients with human colorectal cancer. Cancer 1995; 76:572–8. Citing Literature Volume76, Issue415 August 1995Pages 572-578 ReferencesRelatedInformation