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Cannabinoid receptor mediated inhibition of excitatory synaptic transmission in the rat hippocampal slice is developmentally regulated

2000; Wiley; Volume: 131; Issue: 4 Linguagem: Inglês

10.1038/sj.bjp.0703642

1476-5381

Abdulmonem Al‐Hayani, Stephen N. Davies,

Sleep and Wakefulness Research

The cannabinoid (CB) receptor agonist WIN55,212‐2 (500 n M ) had no effect on the first of a pair of population spikes evoked in the CA1 region of hippocampal slices prepared from young adult (4–6 weeks old) rats, despite powerfully reducing paired‐pulse depression. In contrast WIN55,212‐2 caused a substantial depression of the single population spike (reduced to 43% control) and the field EPSP (reduced to 72% of control) recorded in slices prepared from neonatal (10–13 days old) rats. This effect was stereoselective and blocked by the CB 1 receptor antagonist AM281 (500 n M ). The results indicate that activation of CB 1 receptors inhibits excitatory synaptic transmission in neonatal, but not adult rat hippocampus. This developmental regulation of CB 1 receptor mediated control of excitatory transmission may help explain some, but not all, of the previous discrepancies in the literature. British Journal of Pharmacology (2000) 131 , 663–665; doi: 10.1038/sj.bjp.0703642