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Fenoldopam — A Selective Peripheral Dopamine-Receptor Agonist for the Treatment of Severe Hypertension

2001; Massachusetts Medical Society; Volume: 345; Issue: 21 Linguagem: Inglês

10.1056/nejmra010253

1533-4406

Michael Murphy, Clare Murray, George Shorten,

Renin-Angiotensin System Studies

Fenoldopam is a peripherally acting dopamine-receptor agonist that has vasodilator and diuretic actions. Given intravenously, it is an effective treatment for patients with severe hypertension, including those with hypertensive encephalopathy and perioperative hypertension. This review summarizes the pharmacologic characteristics of fenoldopam and its efficacy as a treatment for patients with severe hypertension.