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Synthesis of 5′-(3,3-Dimethylallyl)-4′-Methoxyethoxymethyl Resacetophenone and Improved Preparation of Broussochalcones A and B

1995; Taylor & Francis; Volume: 7; Issue: 1 Linguagem: Inglês

10.1080/10575639508043191

1057-5634

Diderot Noungoue-tchamo, Denís Barron, Anne‐Marie Mariotte,

Bioactive Compounds and Antitumor Agents

Abstract 5′-(3,3-Dimethylallyl)-4′-methoxyethoxymethyl resacetophenone has been synthesized in 77% yield by para sigmatropic rearrangement of 2′-(3,3-dimethylallyl)-4′-methoxyethoxymethyl resacetophenone. Using this newly synthesized prenyl resacetophenone precursor, the yields of preparation of the naturally occurring broussochalcones A and B have been increased by a factor of 30 and 5, respectively.