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BIBTEX RIS

Antibacterial Activity of Some 5-Dialkylaminomethylhydantoins and Related Derivatives

2013; Pharmaceutical Society of Japan; Volume: 61; Issue: 10 Linguagem: Inglês

10.1248/cpb.c13-00461

ISSN

1347-5223

Autores

Fumiko Fujisaki, Keiko Toyofuku, Mayu Egami, Shiori Ishida, Naho Nakamoto, Nobuhiro Kashige, Fumio Miake, Kunihiro Sumoto,

Tópico(s)

Click Chemistry and Applications

Resumo

In connection with our studies on antibacterial compounds in the class of 5-dialkylaminomethylhydantoins against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) strains, some molecular modifications were attempted. The antibacterial activities of all of the synthesized hydantoin derivatives were evaluated. Among the hydantoin derivatives designed in this study, C2-symmetrical twin-drug type compound (7) showed the highest level of antibacterial activity against S. aureus strain.

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