Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Consequences of obstructive sleep apnea on metabolic profile: A Population‐Based Survey

2013; Wiley; Volume: 21; Issue: 4 Linguagem: Inglês

10.1002/oby.20288

1930-739X

Sônia Maria Togeiro, Gláucia Carneiro, Fernando Flexa Ribeiro Filho, Maria Teresa Zanella, Rogério Santos‐Silva, Jose Augusto Taddei, Lia Bittencourt, Sérgio Tufik,

Sleep and related disorders

Abstract Objective: Epidemiologic studies that control for potential confounders are needed to assess the independent associations of obstructive sleep apnea (OSA) with metabolic abnormalities. The aim of our study was to evaluate the associations of OSA with metabolic abnormalities among the adult population of Sao Paulo, Brazil. Design and Methods: Questionnaires were applied face‐to‐face, full night polysomnography (PSG) was performed, and blood samples were collected in a population‐based survey in Sao Paulo, Brazil, adopting a probabilistic three‐stage cluster sample method. The metabolic profile included fasting glucose, insulin, and lipid levels. The hepatic insulin resistance index was assessed by the homeostasis model assessment‐estimated insulin resistance (HOMA IR ). Results: A total of 1,042 volunteers underwent PSG. Mild OSA and moderate to severe OSA comprised 21.2% and 16.7% of the population, respectively. Subjects with severe to moderate OSA were older, more obese, had higher fasting glucose, HOMA IR , and triglycerides (TG) levels than did the mild and non‐OSA group ( P < 0.001). Multivariate regression analyses showed that an apnea‐hypopnea index (AHI) ≥15 and a time of oxy‐hemoglobin saturation <90% were independently associated with impaired fasting glucose, elevated TG, and HOMA IR . Conclusions: The results of this large cross‐sectional epidemiological study showed that the associations of OSA and metabolic abnormalities were independent of other risk factors.