Amplification of neuromuscular transmission by postjunctional folds
1994; Royal Society; Volume: 258; Issue: 1353 Linguagem: Inglês
10.1098/rspb.1994.0180
ISSN1471-2954
Autores Tópico(s)Ion channel regulation and function
ResumoRestricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Martin A. R. 1994Amplification of neuromuscular transmission by postjunctional foldsProc. R. Soc. Lond. B.258321–326http://doi.org/10.1098/rspb.1994.0180SectionRestricted accessArticleAmplification of neuromuscular transmission by postjunctional folds A. R. Martin Google Scholar Find this author on PubMed Search for more papers by this author A. R. Martin Google Scholar Find this author on PubMed Published:22 December 1994https://doi.org/10.1098/rspb.1994.0180AbstractPreviously, suggestions have been made that postjunctional folds at the vertebrate motor end plate might, in some way, serve to enhance neuromuscular transmission. This suggestion was examined quantitatively using a model junction with geometry similar to that seen in mammalian 'fast twitch' muscles. It was found that the depolarization produced at the top of an interfold by a quantum of acetylcholine is significantly greater than that produced in the absence of folds because of the series resistance of the interfold myoplasm. As a result, voltage-sensitive sodium channels in the postsynaptic membrane are activated more readily. In the model, activation of as few as four interfolds by eight quanta is sufficient for excitation to spread to the remainder of the muscle. With no folds, 19 quanta are required.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. 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Petralia R, Wang Y, Mattson M and Yao P (2018) Invaginating Structures in Mammalian Synapses, Frontiers in Synaptic Neuroscience, 10.3389/fnsyn.2018.00004, 10 This Issue22 December 1994Volume 258Issue 1353 Article InformationDOI:https://doi.org/10.1098/rspb.1994.0180PubMed:21710792Published by:Royal SocietyPrint ISSN:0962-8452Online ISSN:1471-2954History: Manuscript received13/09/1994Manuscript accepted05/10/1994Published online01/01/1997Published in print22/12/1994 License:Scanned images copyright © 2017, Royal Society Citations and impact Large datasets are available through Proceedings B's partnership with Dryad
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