Phospho-serine and phospho-threonine building blocks for the synthesis of phosphorylated peptides by the Fmoc solid phase strategy
1995; Elsevier BV; Volume: 5; Issue: 22 Linguagem: Inglês
10.1016/0960-894x(95)00475-9
ISSN1464-3405
AutoresThomas Vorherr, Willi Bannwarth,
Tópico(s)Click Chemistry and Applications
ResumoThe synthesis of phospho-Ser and phospho-Thr-containing peptides based on Nα-Fmoc-O-(monobenzylphosphono)-Ser and -Thr building blocks is described. The building blocks were obtained by phosphorylation of the Fmoc-protected allyl ester derivatives following oxidation, removal of the allyl-group and selective cleavage of one phospho benzyl ester function with NaI.
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