Changes in densities and kinetics of delayed rectifier potassium channels during neuronal differentiation
1988; Cell Press; Volume: 1; Issue: 8 Linguagem: Inglês
10.1016/0896-6273(88)90172-9
ISSN1097-4199
AutoresGreg L. Harris, Leslie Henderson, Nicholas C. Spitzer,
Tópico(s)Neuroscience and Neural Engineering
ResumoSingle-channel K+ currents were recorded from young and mature spinal neurons cultured from Xenopus embryos to examine the bases of the developmental increases in density and in rate of activation of the macroscopic voltage-dependent delayed rectifier K+ current (IKv). K+ channels of three conductance classes (∼80, 30, and 15 pS) are present at both ages, but only the intermediate and small conductance classes are voltage-dependent and thus underlie IKv. The increase in the density of Kv, is due to increases in the numbers of intermediate and small channels per cell, but not to changes in their open probabilities. The increase in rate of activation of IK, results from a change in the activation kinetics of the intermediate channel class alone.
Referência(s)