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Vitamin D: the neglected neurosteroid?

2001; Elsevier BV; Volume: 24; Issue: 10 Linguagem: Inglês

10.1016/s0166-2236(00)01949-4

1878-108X

John J. McGrath, François Féron, Darryl W. Eyles, Alan Mackay‐Sim,

Vitamin K Research Studies

Recent articles in this journal 1 Rupprecht R. Holsboer F. Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci. 1999; 22: 410-416 Abstract Full Text Full Text PDF PubMed Scopus (608) Google Scholar , 2 Melcangi R.C. Panzica G.C. Steroids in the nervous system: a Pandora's box?. Trends Neurosci. 2001; 24: 311-312 Abstract Full Text Full Text PDF PubMed Scopus (15) Google Scholar have focused attention on the growing body of evidence showing that steroid hormones can alter brain function in novel ways. The autocrine and paracrine roles played by steroids synthesized in the brain (also known as neurosteroids) are yet to be fully elucidated. The physiological properties of known neurosteroids are diverse, and differ temporally (neurodevelopment versus adult brain) and regionally within the brain 3 Baulieu E.E. Neurosteroids: a novel function of the brain. Psychoneuroendocrinology. 1998; 23: 963-987 Abstract Full Text Full Text PDF PubMed Scopus (521) Google Scholar .