From sequences to shapes and back: a case study in RNA secondary structures
1994; Royal Society; Volume: 255; Issue: 1344 Linguagem: Inglês
10.1098/rspb.1994.0040
ISSN1471-2954
AutoresPeter Schuster, Walter Fontana, Peter F. Stadler, Ivo L. Hofacker,
Tópico(s)RNA Research and Splicing
ResumoRestricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Schuster Peter , Fontana Walter , Stadler Peter F. and Hofacker Ivo L. 1994From sequences to shapes and back: a case study in RNA secondary structuresProc. R. Soc. Lond. B.255279–284http://doi.org/10.1098/rspb.1994.0040SectionRestricted accessArticleFrom sequences to shapes and back: a case study in RNA secondary structures Peter Schuster Google Scholar Find this author on PubMed Search for more papers by this author , Walter Fontana Google Scholar Find this author on PubMed Search for more papers by this author , Peter F. Stadler Google Scholar Find this author on PubMed Search for more papers by this author and Ivo L. Hofacker Google Scholar Find this author on PubMed Search for more papers by this author Peter Schuster Google Scholar Find this author on PubMed , Walter Fontana Google Scholar Find this author on PubMed , Peter F. Stadler Google Scholar Find this author on PubMed and Ivo L. Hofacker Google Scholar Find this author on PubMed Published:22 March 1994https://doi.org/10.1098/rspb.1994.0040AbstractRNA folding is viewed here as a map assigning secondary structures to sequences. At fixed chain length the number of sequences far exceeds the number of structures. Frequencies of structures are highly non-uniform and follow a generalized form of Zipf's law: we find relatively few common and many rare ones. By using an algorithm for inverse folding, we show that sequences sharing the same structure are distributed randomly over sequence space. All common structures can be accessed from an arbitrary sequence by a number of mutations much smaller than the chain length. The sequence space is percolated by extensive neutral networks connecting nearest neighbours folding into identical structures. Implications for evolutionary adaptation and for applied molecular evolution are evident: finding a particular structure by mutation and selection is much simpler than expected and, even if catalytic activity should turn out to be sparse in the space of RNA structures, it can hardly be missed by evolutionary processes.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. 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