Artigo Revisado por pares

Norepinephrine efflux evoked by potassium chloride in cat sympathetic nerves: dual mechanism of action

1998; Elsevier BV; Volume: 794; Issue: 1 Linguagem: Inglês

10.1016/s0006-8993(98)00209-1

ISSN

1872-6240

Autores

Toji Yamazaki, Tsuyoshi Akiyama, Toru Kawada, Hirotoshi Kitagawa, Yuji Takauchi, Naoki Yahagi, Kenji Sunagawa,

Tópico(s)

Adenosine and Purinergic Signaling

Resumo

Using a dialysis technique, prominent efflux of norepinephrine (NE) from cardiac sympathetic nerve endings was observed under local administration of potassium chloride (KCl, 100 mM). KCl induced NE efflux was suppressed by ω-conotoxin GVIA or desipramine but residual efflux of NE was still detectable. In the presence of ω-conotoxin GVIA, KCl induced efflux of NE was augmented by pretreatment with reserpine, indicating that this efflux of NE was derived from axoplasma with neurotransporter. These data suggest that a KCl induced brisk increase in dialysate NE levels might occur as a consequence of exocytotic NE release and carrier mediated outward NE transport from nerve endings.

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