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A tour through the transcriptional landscape of platelets

2014; Elsevier BV; Volume: 124; Issue: 4 Linguagem: Inglês

10.1182/blood-2014-04-512756

1528-0020

Sebastian Schubert, Andrew S. Weyrich, Jesse W. Rowley,

MicroRNA in disease regulation

Abstract The RNA code found within a platelet and alterations of that code continue to shed light onto the mechanistic underpinnings of platelet function and dysfunction. It is now known that features of messenger RNA (mRNA) in platelets mirror those of nucleated cells. This review serves as a tour guide for readers interested in developing a greater understanding of platelet mRNA. The tour provides an in-depth and interactive examination of platelet mRNA, especially in the context of next-generation RNA sequencing. At the end of the expedition, the reader will have a better grasp of the topography of platelet mRNA and how it impacts platelet function in health and disease.