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Replication timing and transcriptional control: beyond cause and effect — part III

2016; Elsevier BV; Volume: 40; Linguagem: Inglês

10.1016/j.ceb.2016.03.022

1879-0410

Juan Carlos Rivera‐Mulia, David M. Gilbert,

Epigenetics and DNA Methylation

DNA replication is essential for faithful transmission of genetic information and is intimately tied to chromosome structure and function. Genome duplication occurs in a defined temporal order known as the replication-timing (RT) program, which is regulated during the cell cycle and development in discrete units referred to as replication domains (RDs). RDs correspond to topologically-associating domains (TADs) and are spatio-temporally compartmentalized in the nucleus. While improvements in experimental tools have begun to reveal glimpses of causality, they have also unveiled complex context-dependent relationships that challenge long recognized correlations of RT to chromatin organization and gene regulation. In particular, RDs/TADs that switch RT during development march to the beat of a different drummer.