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Transcription factor networks in erythroid cell and megakaryocyte development

2011; Elsevier BV; Volume: 118; Issue: 2 Linguagem: Inglês

10.1182/blood-2011-04-285981

1528-0020

Louis C. Doré, John D. Crispino,

Hemoglobinopathies and Related Disorders

Abstract Erythroid cells and megakaryocytes are derived from a common precursor, the megakaryocyte-erythroid progenitor. Although these 2 closely related hematopoietic cell types share many transcription factors, there are several key differences in their regulatory networks that lead to differential gene expression downstream of the megakaryocyte-erythroid progenitor. With the advent of next-generation sequencing and our ability to precisely define transcription factor chromatin occupancy in vivo on a global scale, we are much closer to understanding how these 2 lineages are specified and in general how transcription factor complexes govern hematopoiesis.