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Total synthesis of two new dihydrostilbenes from Bulbophyllum odoratissimum

2007; Taylor & Francis; Volume: 9; Issue: 1 Linguagem: Inglês

10.1080/10286020500289543

1477-2213

Weige Zhang, Jinshun Lin, Zeyu Niu, Rui Zhao, D.-L. Liu, N.-L. Wang, Xiaoyang Yao,

Ginseng Biological Effects and Applications

Abstract A total synthetic route of two new dihydrostilbenes 5-(2-benzo[1,3]dioxole-5-ylethyl)-6-methoxy benzo[1,3]dioxole-4-ol (1) and 5-(2-benzo[1,3]dioxole-5-ylethyl)benzo[1,3]dioxole-4,7-diol (2), which were isolated from Bulbophyllum odoratissimum Lindl. with significant cytotoxicity toward human cancer cell lines, was developed via Horner reaction etc. The natural products 1 and 2 were obtained in 10.5% and 3.3% overall yield, respectively. Keywords: DihydrostilbeneTotal synthesis Bulbophyllum odoratissimum Lindl Acknowledgements We gratefully acknowledge Professor Mao-sheng Cheng and Professor Ying-liang Wu, Shenyang Pharmaceutical University, for valuable discussion.