Reactive oxygen species and HIF-1 signalling in cancer
2008; Elsevier BV; Volume: 266; Issue: 1 Linguagem: Inglês
10.1016/j.canlet.2008.02.028
ISSN1872-7980
AutoresΑlex Galanis, Aglaia Pappa, Antonis Giannakakis, Evripidis Lanitis, Denarda Dangaj, Raphael Sandaltzopoulos,
Tópico(s)Adipose Tissue and Metabolism
ResumoThe heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1) represents the key mediator of hypoxia response. HIF-1 controls numerous genes of pivotal importance for cellular metabolism, angiogenesis, cell cycle regulation and inhibition of apoptosis. HIF-1 overexpression and enhanced transcriptional activity are linked to tumour initiation and progression. Malfunction of the HIF-1 signalling network has been associated with breast, ovarian and prostate cancers. Elevated reactive oxygen species (ROS), also observed in such tumours, have been implicated in HIF-1 signalling. Deciphering the role of ROS in cancer onset and their involvement in signalling networks should prove invaluable for the design of novel anticancer therapeutics.
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