Revisão Revisado por pares

Reactive oxygen species and HIF-1 signalling in cancer

2008; Elsevier BV; Volume: 266; Issue: 1 Linguagem: Inglês

10.1016/j.canlet.2008.02.028

ISSN

1872-7980

Autores

Αlex Galanis, Aglaia Pappa, Antonis Giannakakis, Evripidis Lanitis, Denarda Dangaj, Raphael Sandaltzopoulos,

Tópico(s)

Adipose Tissue and Metabolism

Resumo

The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1) represents the key mediator of hypoxia response. HIF-1 controls numerous genes of pivotal importance for cellular metabolism, angiogenesis, cell cycle regulation and inhibition of apoptosis. HIF-1 overexpression and enhanced transcriptional activity are linked to tumour initiation and progression. Malfunction of the HIF-1 signalling network has been associated with breast, ovarian and prostate cancers. Elevated reactive oxygen species (ROS), also observed in such tumours, have been implicated in HIF-1 signalling. Deciphering the role of ROS in cancer onset and their involvement in signalling networks should prove invaluable for the design of novel anticancer therapeutics.

Referência(s)
Altmetric
PlumX