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Systemic T-cell activation in stable angina pectoris

2002; Elsevier BV; Volume: 89; Issue: 6 Linguagem: Inglês

10.1016/s0002-9149(01)02348-7

1879-1913

Lena Jonasson, Carina Linderfalk, Jadwiga Olsson, Anders Wikby, Anders Olsson,

Cytokine Signaling Pathways and Interactions

Besides a local immune response in the arterial wall, 1 Jonasson L Holm J Skalli O Bondjers G Hansson G.K Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis. 1986; 6: 131-138 Crossref PubMed Google Scholar , 2 Hansson G.K Holm J Jonasson L Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol. 1989; 135: 169-175 PubMed Google Scholar there is evidence for a systemic inflammatory and/or immune response in patients with atherosclerotic disease. In unstable angina pectoris (UAP), patients have been shown to have elevated plasma levels of inflammatory markers, such as C-reactive protein, 3 Liuzzo G Biasucci L.M Gallimore J.R Grillo R.L Rebuzzi A.G Pepys M.B Maseri A The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med. 1994; 331: 417-424 Crossref PubMed Scopus (2124) Google Scholar and transient increases in circulating activated T cells. 4 Neri Serneri G.G Prisco D Martini F Gori A.M Brunelli T Poggesi L Rostagno C Gensini G.F Abbate R Acute T cell activation is detectable in unstable angina. Circulation. 1997; 95: 1806-1812 Crossref PubMed Scopus (176) Google Scholar , 5 Caligiuri C Liuzzo G Biasucci L.M Maseri A Immune system activation follows inflammation in unstable angina pathogenic implications. J Am Coll Cardiol. 1998; 32: 1295-1304 Abstract Full Text Full Text PDF PubMed Scopus (94) Google Scholar There is also evidence for a low-grade systemic inflammation in the stable form of coronary artery disease. 6 Ikonomidis I Andreotti F Economou E Stefanadis C Toutouzas P Nihoyannopoulos P Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin. Circulation. 1999; 100: 793-798 Crossref PubMed Scopus (517) Google Scholar , 7 Abdelmouttaleb I Danchin N Ilardo C Aimone-Gastin I Angioi M Lozniewski A Loubinoux J LeFaou A Gueant J.-L C-reactive protein and coronary artery disease additional evidence of the implication of an inflammatory process in acute coronary syndromes. Am Heart J. 1999; 137: 346-351 Abstract Full Text Full Text PDF PubMed Scopus (128) Google Scholar However, there have been few studies on the systemic cell-mediated immune response in stable angina pectoris (SAP), and the data obtained so far have not provided any strong support for continuous T-cell activation. This study examines the T-cell profile, including subsets and activation status of circulating T cells, as well as serum levels of the soluble interleukin-2 receptor (sIL-2R) in SAP.